Remaining important tasks in finding and developing new drugs and vaccines for HIV/AIDS, malaria, cancer and other diseases require continued industry research and development. Industry’s research and development pipeline has produced drugs that have saved AIDS victims previously facing certain death, but still no cure nor vaccine is yet available. Experience with the process of research and development indicates that it requires more than a decade of development to produce a new drug with costs in the hundreds of millions of (...) dollars. Intellectual property protection is critically important in assuring that drug development continues. Partnerships between industry and the public sector have increased access to new therapies in developing countries and promise to enhance access to both patented and generic medicines in the future. (shrink)

Remaining important tasks in finding and developing new drugs and vaccines for HIV/AIDS, malaria, cancer and other diseases require continued industry research and development. Industry’s research and development pipeline has produced drugs that have saved AIDS victims previously facing certain death, but still no cure nor vaccine is yet available. Experience with the process of research and development indicates that it requires more than a decade of development to produce a new drug with costs in the hundreds of millions of (...) dollars. Intellectual property protection is critically important in assuring that drug development continues. Partnerships between industry and the public sector have increased access to new therapies in developing countries and promise to enhance access to both patented and generic medicines in the future. (shrink)

This volume examines the philosophical thought of Dr. Martin Luther King, Jr. and is an assessment of King’s contribution to philosophy—especially ethics, social philosophy and philosophy of religion. It also explores the relevance of King’s thoughts as “liberatory discourse”—insurgent thinking aimed at enabling contemporary social justice.

This volume examines the philosophical thought of Dr. Martin Luther King, Jr. and is an assessment of King’s contribution to philosophy—especially ethics, social philosophy and philosophy of religion. It also explores the relevance of King’s thoughts as “liberatory discourse”—insurgent thinking aimed at enabling contemporary social justice.

Thomas E. Hill, Jr., interprets and extends Kant's moral theory in a series of essays that highlight its relevance to contemporary ethics. He introduces the major themes of Kantian ethics and explores its practical application to questions about revolution, prison reform, and forcible interventions in other countries for humanitarian purposes.

Coping with uncertainty is a necessary part of ordinary life and is crucial to an understanding of how the mind works. For example, it is a vital element in developing artificial intelligence that will not be undermined by its own rigidities. There have been many approaches to the problem of uncertain inference, ranging from probability to inductive logic to nonmonotonic logic. Thisbook seeks to provide a clear exposition of these approaches within a unified framework. The principal market for the book (...) will be students and professionals in philosophy, computer science, and AI. Among the special features of the book are a chapter on evidential probability, which has not received a basic exposition before; chapters on nonmonotonic reasoning and theory replacement, matters rarely addressed in standard philosophical texts; and chapters on Mill's methods and statistical inference that cover material sorely lacking in the usual treatments of AI and computer science. (shrink)

The moral significance of preserving natural environments is not entirely an issue of rights and social utility, for a person’s attitude toward nature may be importantly connected with virtues or human excellences. The question is, “What sort of person would destroy the natural environment--or even see its value solely in cost/benefit terms?” The answer I suggest is that willingness to do so may well reveal the absence of traits which are a natural basis for a proper humility, self-acceptance, gratitude, and (...) appreciation of the good in others. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Minding Brain Injury, Consciousness, and Ethics: Discourse and DeliberationsJoseph J. Fins (bio) and James Giordano (bio)The annual John Collins Harvey Lecture at the Georgetown University’s Pellegrino Center for Clinical Bioethics is a forum for addressing contemporary topics at the intersection of medicine and bioethics. This year, in marking the decadal anniversary of the launch of the Brain Research through Advancing Innovative Neurotechnology (BRAIN) Initiative, the Harvey Lecture (...) provided an interactive discussion with renowned clinician, researcher, scholar, and author, Joseph J. Fins, MD—who is the E. William Davis, Jr., MD Professor of Medical Ethics, Chief of the Division of Medical Ethics, and a Professor of Medicine at Weill Cornell Medical College—conducted by James Giordano, PhD, MPhil—who is a Professor of Neurology and Biochemistry, and Chief of the Pellegrino Center’s Neuroethics Studies Program at the Georgetown University Medical Center. The discourse focused upon the topic of covert consciousness, and the ways in which current and developing brain science technologies, together with revised practices of medicine, in general, may afford new opportunities in patient care, but may also give rise to issues, questions, challenges, and opportunities for neuroethics.Prof. James GIORDANO:Prof. Fins, your most recent book, Rights Come to Mind: Brain Injury, Ethics, and the Struggle for Consciousness (Fins 2015), addresses your ongoing work to employ current and emerging neurological approaches to reveal conscious functions in patients with profound brain injury and disease. To be sure, the destination—if you will—is to talk about covert consciousness. But in commencing this discussion, I’d like to propose a route, which traces your professional journey to this point in your career, and how it led you on your search to reveal consciousness in those patients who lack expressive capability. You went into palliative care first, and that brought you to where you are today. [End Page 227]Prof. Joseph J. FINS:First, let me thank you and the Pellegrino Center for the honor of giving the John Harvey Collins Lecture in such an interactive manner. The forefront of neurological care—and the neuroethical issues and methods focal to such practice—wasn’t what I initially intended to do professionally, but I think that therein is a good lesson for young people’s career aspirations. Simply put, one doesn’t always know where they’ll end up at the beginning of the journey, and as Kierkegaard said, life is lived forward, but is understood backwards (Kierkegaard 1843).In the nineties and the early 2000s, I was trying to help improve the quality of care of people at the end of life, and I wrote a book, entitled The Palliative Ethic of Care: Clinical Wisdom at Life’s End (Fins 2006), in which I addressed notions of phronesis—practical wisdom—in integrating theory and practice toward improving how people die. I became interested in the Quinlan case (Quinlan 1976), and the right to die, and around the same time, I ran into a colleague of mine at Cornell: Dr. Nicholas D. Schiff. Dr. Schiff is a neurologist, who was a protégé of Fred Plum, who was the originator of the concept of the vegetative state with Bryan Jennett, back in 1972. Fred was both of our teachers here at Cornell. Niko (Dr. Schiff) was interested in patients with disorders of consciousness, and was beginning to envision doing work—that ultimately, we did—using deep brain stimulation (DBS) to try to treat patients in the minimally conscious state, a category that was subsequently codified in 2002.I realized that a whole population of people—with these disorders of consciousness—had been somewhat marginalized, and their neglect essentially devolves back to the considerations of the right to die. The right to die was established in the Quinlan case because Judge Hughes—the presiding chief judge of the New Jersey Supreme Court—talked about Ms. Quinlan’s loss of a cognitive, sapient state as being the moral warrant for her right to die, given the fact that it was viewed as a futile situation. I recognized, over the ensuing years—from my background in palliative and end-of-life care—[1] that we had over-generalized notions of futility... (shrink)

The moral significance of preserving natural environments is not entirely an issue of rights and social utility, for a person’s attitude toward nature may be importantly connected with virtues or human excellences. The question is, “What sort of person would destroy the natural environment--or even see its value solely in cost/benefit terms?” The answer I suggest is that willingness to do so may well reveal the absence of traits which are a natural basis for a proper humility, self-acceptance, gratitude, and (...) appreciation of the good in others. (shrink)

These essays are characterized by meticulous argument in the analytical tradition. The book concerns matters of metaphysics in a broad sense: philosophy of mind and the problems of subjectivity; questions concerning nomological and statistical laws of nature; and, as we would expect, chance and induction.

Contemporary discussions of practical reason often refer vaguely to the Kantian conception of reasons as an alternative to various means-ends theories, but it is rarely clear what this is supposed to be, except that somehow moral concerns are supposed to fare better under the Kantian conception. The theories of Nagel, Gewirth, Darwall, and Donagan have been labeled “Kantian” because they deviate strikingly from standard preference models, but their roots in Kant have not been traced in detail and important differences may (...) go unnoticed. All this is not surprising, of course, because Kant’s conception of practical reason is inseparable from his ideas of freedom, which are notoriously difficult and controversial. It is hard enough to characterize these ideas accurately in Kantian terminology, harder still to explain them in terms of contemporary debates about reasons for action. (shrink)

If someone comes to my house, saying, "Here is a bone; I hope Obrecht likes it," I might answer with a deductive argument: "You may rest assured on that score. Obrecht is a dog, and all dogs like bones; therefore Obrecht will like it." We may formalize this argument as follows: Let G be the bone, O be Obrecht, D be the class of dogs, B be the class of bones, and, finally, let L be the class of ordered pairs (...) such that x likes y. The premises are then: x ∈ D ⋅ y ∈ B ⋅ ⊃ ∈ L) G ∈ B O ∈ D. (shrink)

[The Catcher in the Rye's] catalogue of characters, incidents, expressions could be extended indefinitely, all of them suggesting that Holden's sickness of soul is something deeper than economic or political, that his revulsion at life is not limited to social and monetary inequities, but at something in the nature of life itself - the decrepitude of the aged, the physical repulsiveness of the pimpled, the disappearance and dissolution of the dead, the terrors of sex, the hauntedness of human aloneness, the (...) panic of individual isolation. Headlines about Korea, Dean Acheson, and the cold war seem, if not irrelevant, essentially wide of the mark - if we define the mark as the heart and soul of Catcher. James E. Miller, Jr., author of "Henry James in Reality" and numerous books and articles on American literature, responds in this essay to Carol and Richard Ohmann's "Reviewers, Critics, and The Catcher in the Rye. The Ohmann's answer will appear in our summer issue. (shrink)

In working his way through his complex conception of the relation of fiction and reality, [Henry] James thus found the unconscious moral dimension inextricably embedded within "realism" itself. In following the threads of realism back to consciousness itself, James invariably found there intertwined with its roots those aspects and elements that other theorists kept carefully separate. By exploring experience to its source, he found imagination. By following objective life from "out there" to conception, he found individual vision. By following the (...) seeming oneness of the passing show back to perception, he found infinite variation and multiplicity. By following the uncolored flux and flow of events to their embodiment in the fictional medium, he found coloration of personality. And by following the "felt life" back to the artist's "prime sensibility", James found there the "moral sense" and the "enveloping air of the artist's humanity"—that which gives "the last touch to the worth of a work." James E. Miller, Jr., professor of English at the University of Chicago, is the author of A Critical Guide to Leaves of Grass; Walt Whitman; F. Scott Fitzgerald: His Art and His Technique; J.D. Salinger; Theory of Fiction: Henry James; and numerous articles on American literature and education. He contributed "Catcher In and Out of History" to Critical Inquiry, Spring 1977. (shrink)

Ralph Waldo Emerson said, “a Foolish consistency is the hobgoblin of little minds, adored by little statesmen and philosophers and divines.” The alleged evidence has mounted that ordinary folk are prone to inconsistency, and particularly that they are prone to inconsistency when it comes to probabilistic judgments. I write “alleged,” because it is open to question whether the experiments that provide this evidence are well designed—in particular whether Quine’s principle of logistical charity has been followed. I also do so because (...) in some cases of probability judgments the untutored intuitions of ordinary people seem to be at least as good as, and perhaps better than, the intuitions of those who run the experiments. (shrink)

Is Kantian Ethics guilty of utopian thinking? First, potentially good and bad uses of utopian ideals are distinguished, then an apparent path is traced from Rousseau’s unworkable political ideal to Kant’s ethical ideal. Three versions of Kant’s Categorical Imperative are examined briefly for the ways that they may raise the suspicion that they manifest or encourage bad utopian thinking. In each case Kantians have available responses to counter the suspicion, but special attention is directed to the version that says “Act (...) on the maxims of a universally law–giving member of a kingdom of ends.” Interpretations vary, but here primary focus is on one contemporary reconstruction and development of this central idea. Several objections suggest that this idea encourages bad utopian thinking are briefly addressed: that we cannot count on everyone to follow ideal rules, that even conscientious people disagree in their moral judgments, and that theories that allow exceptions to familiar moral rules create a “slippery slope” to moral chaos. (shrink)

Contemporary discussions of practical reason often refer vaguely to the Kantian conception of reasons as an alternative to various means-ends theories, but it is rarely clear what this is supposed to be, except that somehow moral concerns are supposed to fare better under the Kantian conception. The theories of Nagel, Gewirth, Darwall, and Donagan have been labeled “Kantian” because they deviate strikingly from standard preference models, but their roots in Kant have not been traced in detail and important differences may (...) go unnoticed. All this is not surprising, of course, because Kant’s conception of practical reason is inseparable from his ideas of freedom, which are notoriously difficult and controversial. It is hard enough to characterize these ideas accurately in Kantian terminology, harder still to explain them in terms of contemporary debates about reasons for action. (shrink)

In a morally perfect world we would not face many of the hard choices which confront us in the real world. If everyone were fully conscientious, moral dilemmas might still be posed by natural circumstances; but many of our most difficult and tragic choices would not arise. In particular, we would never need to decide whether we should ourselves do a lesser evil in order to prevent someone else from doing a greater one. Unfortunately we do not live in such (...) a perfect world. Through greed, malice, jealousy, false pride, or whatever, people are prepared to commit the most heinous crimes against innocent victims; and sometimes, it seems, they can be prevented only by means which no one would consider in the morally perfect world. One must choose among evils; doing a lesser evil oneself or allowing others to do an even greater evil. (shrink)

Tom Regan criticizes my thesis that obligation toward the environment is grounded in a world view and thereby has a moral overridingness which mere interests and desires do not have. He holds that my approach is too subjectivistic. I counter, first, by explaining that phenomenology, which I use in my analysis of moral obligation, is not subjectivistic in the way emotivism or prescriptivism inethics is subjectivistic. Second, I argue that world views are products of learning and experience of one shared (...) world, that most world views share large areas of agreement, and that they can be argued for and criticized. (shrink)

Making consent work for its primary purposes has been, and will be, a challenge. Millum and Bromwich have done an excellent job of considering the manifold obligations of informed consent, with the...

This essay underscores the significant contribution Firestone and Jacobs make through the very thorough way their book surveys the wide range of recent scholarship bearing on Kant’s Religion. The essay then argues, however, that the complex scaffolding designed to summarize and categorize the varied responses to Kant has the effect of muting the authors’ own very bold interpretive stance. This point is particularly true with respect to their account of the compatibility of Kant’s Religion with the Christian tradition. In addition, (...) the essay suggests that the judicial metaphor of “defense” is overplayed, forcing certain interpretations of Kant into potentially misleading positions for the sake of the interpretive scheme. (shrink)

In a morally perfect world we would not face many of the hard choices which confront us in the real world. If everyone were fully conscientious, moral dilemmas might still be posed by natural circumstances; but many of our most difficult and tragic choices would not arise. In particular, we would never need to decide whether we should ourselves do a lesser evil in order to prevent someone else from doing a greater one. Unfortunately we do not live in such (...) a perfect world. Through greed, malice, jealousy, false pride, or whatever, people are prepared to commit the most heinous crimes against innocent victims; and sometimes, it seems, they can be prevented only by means which no one would consider in the morally perfect world. One must choose among evils; doing a lesser evil oneself or allowing others to do an even greater evil. (shrink)

Ralph Waldo Emerson said, “a Foolish consistency is the hobgoblin of little minds, adored by little statesmen and philosophers and divines.” The alleged evidence has mounted that ordinary folk are prone to inconsistency, and particularly that they are prone to inconsistency when it comes to probabilistic judgments. I write “alleged,” because it is open to question whether the experiments that provide this evidence are well designed—in particular whether Quine’s principle of logistical charity has been followed. I also do so because (...) in some cases of probability judgments the untutored intuitions of ordinary people seem to be at least as good as, and perhaps better than, the intuitions of those who run the experiments. (shrink)

Environmental holism has been accused of being totalitarian because it subsumes the interests and rights of individuals under the good of the whole biosphere, thus rejecting humanistic ethics. Whether this is true depends on the type of holism in question. Only an extreme form of holism leads to this totalitarian approach, and that type of holism should be rejected, not alone because it leads to unacceptable practices, but because it is too abstract and reductionistic to be an adequate basis for (...) ethics. (shrink)